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Although after ingestion folic acid is readily reduced by dihydrofolate reductase and converted to the THF folate forms, this is a very slow and variable process (Bailey & Ayling, 2009), and thus exposure to high oral doses of folic acid can result in the appearance of unmetabolised folic acid which is not a normal constituent of plasma or other tissues and may have adverse metabolic effects

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“Heme catalyzes very specific types of chemical reactions,” said Brown, “that transform abundant, simple nutrients into this explosion of hundreds of diverse volatile odorant molecules